There is solid and mounting evidence that the causes are related to gut flora, from multiple studies which have shown that colicky babies have different gut flora patterns, which includes a lack of Lactobacillus acidophilus. Some of these studies suggest the administering of a probiotic, such as Lactobacillus acidophilus, will improve the condition. Probiotics have been shown to improve other conditions associated with colic, such as lactose intolerance, necrotizing enterocolitis[6], and gastric inflammation. In addition to that probiotics have been shown to generally improve the health of children who take them.
Some doctors claim that it is a combination of a baby's sensitive temperament, the environment, and its immature nervous system which makes it cry easily and without control. Others believe that it originates in problems in the baby's digestive system, specifically because of the buildup of gas which cannot be released. New studies at the Colic Clinic at Brown University demonstrate that nearly half of babies with colic have mild gastroesophageal reflux. Some cases may be the result of lactose intolerance.
Recent research raises a number of hypotheses including the onset of melatonin production by the pineal gland (which does not begin until 12 weeks of age, about the time colic seems to disappear), circadian rhythms, and smoking and stress of the mother in the third trimester.
Because of the links between prenatal stress, birth trauma, maternal stress etc, and colic, it has also been suggested that some 'colic', or excessive crying may actually be a healthy stress release requiring support and facilitation rather than suppression or 'cure'.
Treatment
There is currently no generally-accepted medical treatment for colic, and the approach taken by medical professionals varies substantially from country to country and indeed from doctor to doctor. Many believe that the condition is currently untreatable, and is best left to run its course. Other doctors prescribe simethicone, which treats trapped gas; some parents report that this is effective, but for many others it is not, and research suggests that it is not useful.
One study showed a moderate success when infants with colic were treated with dicyclomine, an anti-spasmotic drug commonly found in some anti-diarrheal medications.
Other studies have found success with probiotics such as Lactobacillus reuteri, which were intended to reduce gas.
Gripe water is believed by some to relieve the symptoms associated with baby colic, teething and baby's gas[citation needed].
In addition to herbal teas it is believed that the organoleptic effects of certain herbs can help calm and relieve colic symptoms.
Scientists warn that further studies are necessary before any specific cure should be recommended.
There is general agreement that soothing measures, such as pacifiers, listening to white noise and rocking, are often effective in calming the baby during crying periods. Also known as the "cuddle cure", the five S's are known as Swaddling, placing the baby on their Side or Stomach, Swinging the baby, making a Shhh sound in the baby's ear, and giving the baby something to Suck on. Some parents take turns holding the baby upright (which may reduce the pain and crying) to enable the other parent to catch up on sleep. Babies with lactose intolerance or reflux cry harder and longer when left to lie on their backs, but parents are not advised to put the baby to sleep on their front as it is considered a risk factor for Sudden Infant Death Syndrome.
Various tactics, such as changes in diet or routine, an increase in fresh air or certain herbal teas, are popularly believed to cure colic. There is also the theory that rubbing warm olive oil on the hands and feet, then rubbing the stomach with olive oil in a clockwise motion will cure colic. While some of these may help in certain cases, none of them is known to be universally effective. The widespread belief in them may be partly due to the suddenness with which colic naturally resolves itself. Many parents keep trying different approaches until the colic suddenly stops, at which point they presume that the last thing they tried was the cure.
In cases where 'colic' or excessive crying is possibly the infants innate healing mechanism helping them to recover from birth trauma or other past or current stress, appropriate holding and facilitation techniques may be able to increase the effectiveness of the release process and reduce the overall amount of crying time needed. In any case parents may benefit from learning these techniques, as this can help them to cope better psychologically with their child's distress, and to feel more empowered in the midst of an extremely trying situation.